Papagiannakopoulos (PapaG) Lab

Our laboratory uses genetically engineered mouse models that enable the study of the complex genetic, immune, and metabolic factors that contribute to cancer pathophysiology.

Cancer is a multistep process that involves the complex interplay of both genetic and environmental factors that contribute to tumor progression. Our laboratory uses genetically engineered mouse models, which recapitulate the genetics, heterogeneity, histological progression, and tissue microenvironment of human tumors. Using these mouse models, we can dissect the interactions of cancer cells and the tumor microenvironment and determine how systemic changes in metabolism, physiology, and diet can impact tumor progression.